Systematic Reviews of Diagnostic Studies (online)

The number of primary studies evaluating diagnostic tests is rising. Critically summarizing such studies in a systematic review is beneficial for health care professionals seeking the best evidence about the use of diagnostic tests. Reviews of diagnostic studies are more challenging because of more variation in questions & designs, specific sources of bias & variation, and the need to use more complex statistical approaches to meta-analysis. Several advances have recently been made in the methods to perform such reviews.

In this course we discuss and practice the methods to assess the methodological quality of primary diagnostic test accuracy studies (QUADAS-2 instrument), the statistical models to meta-analyze the paired measures of test accuracy (bivariate meta-regression model of sensitivity and specificity), and how to critically read and interpret the findings of systematic review of diagnostic studies. The course consists of plenary presentations, small-group discussions, and computer exercises using the statistical software package R.

At the end of the course, you should be able to:

• appreciate the diversity of test usage and study designs
• understand potential risk of bias and concerns regarding applicability
• understand the concept underlying approaches to meta-analysis
• explore heterogeneity and compare test accuracy
• create different types of analysis
• summarize results and draw appropriate conclusions

Our courses are aimed at clinical researchers, nurses, general practitioners, and other health professionals who want to improve their skills in epidemiology, statistics and (clinical) research.

3 weeks, 14 hours per week (online)

Even though you can manage your own time our courses are not intended as individual education. We offer personalized online learning with lots of interaction with peer students, the E-moderator and lecturers. Flexibility from students, a positive attitude towards teachers and peers and the willingness to learn together and help each other is invaluable to our courses. To experience maximum interaction, we advise you to log on several times per week.

Note that the starting dates of courses, interim deadlines, and dates of exams are fixed, but you can choose when and where you want to watch web lectures and work on assignments. The e-moderator of the course will inform you about the beginning of the course and about deadlines during the course.

The average required study workload for the courses of MSc Epidemiology Postgraduate Online is 14 hours per week. You will need this time to study, to keep up with the assignments and course material.

Please note that this course is part of an existing program within the Graduate School of Life Sciences.